| EC |
2.1.1.173 |
| Accepted name: |
23S rRNA (guanine2445-N2)-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + guanine2445 in 23S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA |
| Other name(s): |
ycbY (gene name); rlmL (gene name) |
| Systematic name: |
S-adenosyl-L-methionine:23S rRNA (guanine2445-N2)-methyltransferase |
| Comments: |
The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate [1]. The enzyme specifically methylates guanine2445 at N2 in 23S rRNA. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Lesnyak, D.V., Sergiev, P.V., Bogdanov, A.A. and Dontsova, O.A. Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. J. Mol. Biol. 364 (2006) 20–25. [DOI] [PMID: 17010378] |
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| [EC 2.1.1.173 created 1976 as EC 2.1.1.52, part transferred 2010 to EC 2.1.1.173] |
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