The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA . The enzyme specifically methylates guanine1207 at N2 in 16S rRNA.
Tscherne, J.S., Nurse, K., Popienick, P. and Ofengand, J. Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli. J. Biol. Chem.274 (1999) 924–929. [PMID: 9873033]
Sunita, S., Purta, E., Durawa, M., Tkaczuk, K.L., Swaathi, J., Bujnicki, J.M. and Sivaraman, J. Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC. Nucleic Acids Res.35 (2007) 4264–4274. [PMID: 17576679]
[EC 18.104.22.168 created 1976 as EC 22.214.171.124, part transferred 2010 to EC 126.96.36.199]