The Enzyme Database

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EC 2.1.1.142     
Accepted name: cycloartenol 24-C-methyltransferase
Reaction: S-adenosyl-L-methionine + cycloartenol = S-adenosyl-L-homocysteine + (24R)-24-methylcycloart-25-en-3β-ol
For diagram of sterol-sidechain modification, click here
Other name(s): sterol C-methyltransferase
Systematic name: S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase
Comments: S-Adenosyl-L-methionine methylates the Si face of the 24(25)-double bond with elimination of a hydrogen atom from the pro-Z methyl group at C-25.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 50936-46-4
References:
1.  Mangla, A.T. and Nes, W.D. Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition. Bioorg. Med. Chem. 8 (2000) 925. [PMID: 10882005]
[EC 2.1.1.142 created 2001]
 
 


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