ExplorEnz: EC 2.1.1.130

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2.1.1.130

Accepted name:

precorrin-2 C²⁰-methyltransferase

Reaction:

S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A

For diagram of corrin and siroheme biosynthesis (part 2), click here

Systematic name:

S-adenosyl-L-methionine:precorrin-2 C²⁰-methyltransferase

Comments:

This enzyme participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway. See EC 2.1.1.151, cobalt-factor II C²⁰-methyltransferase, for the equivalent enzyme that participates in the anaerobic cobalamin biosynthesis pathway.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 131554-12-6

References:

1.	Roessner, C.A., Warren, M.J., Santander, P.J., Atshaves, B.P., Ozaki, S., Stolowich, N.J., Iida, K., Scott, A.I. Expression of Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis. FEBS Lett. 301 (1992) 73–78. [DOI] [PMID: 1451790]
2.	Roessner, C.A., Spencer, J.B., Ozaki, S., Min, C., Atshaves, B.P., Nayar, P., Anousis, N., Stolowich, N.J., Holderman, M.T., Scott, A.I. Overexpression in Escherichia coli of 12 vitamin B₁₂ biosynthetic enzymes. Protein Extr. Purif. 6 (1995) 155–163. [DOI] [PMID: 7606163]
3.	Debussche, L., Thibaut, D., Cameron, B., Crouzet, J. and Blanche, F. Biosynthesis of the corrin macrocycle of coenzyme B₁₂ in Pseudomonas denitrificans. J. Bacteriol. 175 (1993) 7430–7440. [DOI] [PMID: 8226690]

[EC 2.1.1.130 created 1999]