The Enzyme Database

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EC 2.1.1.128     
Accepted name: (RS)-norcoclaurine 6-O-methyltransferase
Reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine
For diagram of reticuline biosynthesis, click here
Glossary: norcoclaurine = 6,7-dihydroxy-1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline
Systematic name: S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase
Comments: The enzyme will also catalyse the 6-O-methylation of (RS)-norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 89700-33-4
References:
1.  Rueffer, M., Nagakura, N., Zenk, M.H. Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransferase from Argemone platyceras cell cultures. Planta Med. 49 (1983) 131–137.
2.  Sato, F., Tsujita, T., Katagiri, Y., Yoshida, S. and Yamada, Y. Purification and characterization of S-adenosyl-L-methionine:norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells. Eur. J. Biochem. 225 (1994) 125–131. [PMID: 7925429]
3.  Stadler, R., Zenk, M.H. A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline. Liebigs Ann. Chem. (1990) 555–562.
[EC 2.1.1.128 created 1999]
 
 


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