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Accepted name: 3′-hydroxy-
N-methyl-( S)-coclaurine 4′- O-methyltransferase
S-adenosyl- L-methionine + 3′-hydroxy- N-methyl-( S)-coclaurine = S-adenosyl- L-homocysteine + ( S)-reticuline
For diagram of reticuline biosynthesis,
S-adenosyl- L-methionine:3′-hydroxy- N-methyl-( S)-coclaurine 4′- O-methyltransferase
Comments: Involved in isoquinoline alkaloid metabolism in plants. The enzyme has also been shown to catalyse the methylation of (
RS)-laudanosoline, ( S)-3′-hydroxycoclaurine and ( RS)-7- O-methylnorlaudanosoline.
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 132084-81-2
Frenzel, T., Zenk, M.H. S-Adenosyl-
L-methionine: 3′-hydroxy- N-methyl-( S)-coclaurine 4′- O-methyltransferase, a regio- and stereoselective enzyme of the ( S)-reticuline pathway. Phytochemistry 29 (1990) 3505–3511.
[EC 188.8.131.52 created 1999]
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