| EC |
1.2.1.51 |
| Accepted name: |
pyruvate dehydrogenase (NADP+) |
| Reaction: |
pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH |
| Glossary: |
methyl viologen = 1,1′-dimethyl-4,4′-bipyridine-1,1′-diium |
| Systematic name: |
pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating) |
| Comments: |
The Euglena enzyme can also use FAD or methyl viologen as acceptor, more slowly. The enzyme is inhibited by oxygen. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 93389-35-6 |
| References: |
| 1. |
Inui, H., Miyatake, K., Nakano, Y. and Kitaoka, S. Occurrence of oxygen-sensitive, NADP +-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis. J. Biochem. (Tokyo) 96 (1984) 931–934. [PMID: 6438078] |
| 2. |
Inui, H., Ono, K., Miyatake, K., Nakano, Y. and Kitaoka, S. Purification and characterization of pyruvate:NADP+ oxidoreductase in Euglena gracilis. J. Biol. Chem. 262 (1987) 9130–9135. [PMID: 3110154] |
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| [EC 1.2.1.51 created 1989] |
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