The Enzyme Database

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Accepted name: dimethylsulfoxide reductase
Reaction: dimethylsulfide + menaquinone + H2O = dimethylsulfoxide + menaquinol
For diagram of dimethyl sulfide catabolism, click here
Other name(s): DMSO reductase
Systematic name: dimethyl sulfide:menaquinone oxidoreductase
Comments: Contains molybdopterin and [4Fe-4S] clusters. Also reduces pyridine N-oxide and trimethylamine N-oxide, with lower activity, to the corresponding amines.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Simala-Grant, J.L. and Weiner, J.H. Kinetic analysis and substrate specificity of Escherichia coli dimethyl sulfoxide reductase. Microbiology 142 (1996) 3231–3239. [DOI] [PMID: 8969520]
2.  Daruwala, R. and Meganathan, R. Dimethyl sulfoxide reductase is not required for trimethylamine N-oxide reduction in Escherichia coli. FEMS Microbiol. Lett. 67 (1991) 255–259. [PMID: 1769531]
3.  Miguel, L. and Meganthan, R. Electron donors and the quinone involved in dimethyl sulfoxide reduction in Escherichia coli. Curr. Microbiol. 22 (1991) 109–115.
4.  Rothery, R.A., Trieber, C.A. and Weiner, J.H. Interactions between the molybdenum cofactor and iron-sulfur clusters of Escherichia coli dimethylsulfoxide reductase. J. Biol. Chem. 274 (1999) 13002–13009. [DOI] [PMID: 10224050]
[EC created 2011]

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