EC |
1.8.4.7 |
Accepted name: |
enzyme-thiol transhydrogenase (glutathione-disulfide) |
Reaction: |
[xanthine dehydrogenase] + glutathione disulfide = [xanthine oxidase] + 2 glutathione |
Other name(s): |
[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase; enzyme-thiol transhydrogenase (oxidized-glutathione); glutathione-dependent thiol:disulfide oxidoreductase; thiol:disulphide oxidoreductase |
Systematic name: |
[xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase |
Comments: |
Converts EC 1.17.1.4 xanthine dehydrogenase into EC 1.17.3.2 xanthine oxidase in the presence of glutathione disulfide; also reduces the disulfide bond of ricin. Not inhibited by Cu2+ or thiol reagents. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 85030-79-1 |
References: |
1. |
Battelli, M.G. and Lorenzoni, E. Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver. Biochem. J. 207 (1982) 133–138. [PMID: 6960894] |
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[EC 1.8.4.7 created 1989, modified 2002] |
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