The Enzyme Database

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Accepted name: L-methionine (R)-S-oxide reductase
Reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin
For diagram of reaction, click here and for mechanism of reaction, click here
Other name(s): fRMsr; FRMsr; free met-R-(o) reductase; free-methionine (R)-S-oxide reductase
Systematic name: L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming]
Comments: Requires NADPH. Unlike EC, peptide-methionine (R)-S-oxide reductase, this enzyme cannot use peptide-bound methionine (R)-S-oxide as a substrate [1]. Differs from EC, L-methionine (S)-S-oxide in that L-methionine (S)-S-oxide is not a substrate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 945954-12-1
1.  Etienne, F., Spector, D., Brot, N. and Weissbach, H. A methionine sulfoxide reductase in Escherichia coli that reduces the R enantiomer of methionine sulfoxide. Biochem. Biophys. Res. Commun. 300 (2003) 378–382. [PMID: 12504094]
[EC created 1984 as EC, part transferred 2006 to EC]

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