The Enzyme Database

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EC 1.8.3.5     
Accepted name: prenylcysteine oxidase
Reaction: an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2
Other name(s): prenylcysteine lyase
Systematic name: S-prenyl-L-cysteine:oxygen oxidoreductase
Comments: A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC 4.4.1.18.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 196717-99-4
References:
1.  Zhang, L., Tschantz, W.R. and Casey, P.J. Isolation and characterization of a prenylcysteine lyase from bovine brain. J. Biol. Chem. 272 (1997) 23354–23359. [PMID: 9287348]
2.  Tschantz, W.R., Digits, J.A., Pyun, H.J., Coates, R.M. and Casey, P.J. Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. J. Biol. Chem. 276 (2001) 2321–2324. [PMID: 11078725]
[EC 1.8.3.5 created 2000 as EC 4.4.1.18, transferred 2002 to EC 1.8.3.5]
 
 


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