The enzyme is found in sulfate-reducing bacteria. The source of the electrons is molecular hydrogen, via EC 22.214.171.124, cytochrome-c3 hydrogenase. The organisms utilize the sulfite that is produced for energy generation by EC 126.96.36.199, dissimilatory sulfite reductase.
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Ishimoto, M., Toyama, J. Biochemical studies on sulfate reducing bacteria. VI. Separation of hydrogenase and thiosulfate reductase and partial purification of cytochrome and green pigment. J. Biochem. (Tokyo)44 (1957) 233–242.
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