Accepted name: thioredoxin-disulfide reductase
Reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+
Glossary: The term ’oxidized thioredoxin’ has been replaced by ’thioredoxin disulfide’ as the former is ambiguous
Other name(s): NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase
Systematic name: thioredoxin:NADP+ oxidoreductase
Comments: A flavoprotein (FAD).
1.  Moore, E.C., Reichard, P. and Thelander, L. Enzymatic synthesis of deoxyribonucleotides. V. Purification and properties of thioredoxin reductase from Escherichia coli B. J. Biol. Chem. 239 (1964) 3445–3452. [PMID: 14245401]
2.  Speranza, M.L., Ronchi, S. and Minchiotti, L. Purification and characterization of yeast thioredoxin reductase. Biochim. Biophys. Acta 327 (1973) 274–281. [PMID: 4149839]
3.  Arner, E.S. and Holmgren, A. Physiological functions of thioredoxin and thioredoxin reductase. Eur. J. Biochem. 267 (2000) 6102–6109. [PMID: 11012661]
[EC created 1972 as EC, transferred 2002 to EC]

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