ExplorEnz: EC 1.8.1.15

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1.8.1.15

Accepted name:

mycothione reductase

Reaction:

2 mycothiol + NAD(P)⁺ = mycothione + NAD(P)H + H⁺

Glossary:

mycothiol = 1-O-[2-(N²-acetyl-L-cysteinamido)-2-deoxy^--D-glucopyranosyl]-1D-myo-inositol
mycothione = oxidized (disulfide) form of mycothiol

Other name(s):

mycothiol-disulfide reductase

Systematic name:

mycothiol:NAD(P)⁺ oxidoreductase

Comments:

Contains FAD. No activity with glutathione, trypanothione or coenzyme A as substrate.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 252212-92-3

References:

1.	Patel, M.P. and Blanchard, J.S. Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase. Biochemistry 38 (1999) 11827–11833. [DOI] [PMID: 10512639]
2.	Patel, M.P. and Blanchard, J.S. Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects. Biochemistry 40 (2001) 5119–5126. [DOI] [PMID: 11318633]

[EC 1.8.1.15 created 2002]