Contains FAD. The enzyme, which is found only in halobacteria, maintains the concentration of γ-glutamylcysteine, the major low molecular weight thiol in halobacteria. Not identical with EC 22.214.171.124 (glutathione-disulfide reductase) or EC 126.96.36.199 (CoA-disulfide reductase).
Sundquist, A.R. and Fahey, R.C. The novel disulfide reductase bis-γ-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes. J. Bacteriol.170 (1988) 3459–3467. [DOI] [PMID: 3136140]
Sundquist, A.R. and Fahey, R.C. The function of γ-glutamylcysteine and bis-γ-glutamylcystine reductase in Halobacterium halobium. J. Biol. Chem.264 (1989) 719–725. [PMID: 2910862]
Kim, J. and Copley, S.D. The orphan protein bis-γ-glutamylcystine reductase joins the pyridine nucleotide disulfide reductase family. Biochemistry52 (2013) 2905–2913. [DOI] [PMID: 23560638]
[EC 188.8.131.52 created 1992 as EC 184.108.40.206, transferred 2002 to EC 220.127.116.11, modified 2013]