The Enzyme Database

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Accepted name: N-hydroxy-2-acetamidofluorene reductase
Reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+
Other name(s): N-hydroxy-2-acetylaminofluorene reductase; NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase
Systematic name: 2-acetamidofluorene:NAD(P)+ oxidoreductase
Comments: Also acts, more slowly, on N-hydroxy-4-acetamidobiphenyl.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 99890-08-1
1.  Gutmann, H.R. and Erickson, R.R. The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction. J. Biol. Chem. 244 (1969) 1729–1740. [PMID: 5780838]
2.  Kitamura, S. and Tatsumi, K. Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol. Biochem. Biophys. Res. Commun. 133 (1985) 67–74. [PMID: 4074379]
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