The Enzyme Database

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EC 1.6.5.12     
Accepted name: demethylphylloquinone reductase
Reaction: demethylphylloquinone + NADPH + H+ = demethylphylloquinol + NADP+
Glossary: demethylphylloquinone = 2-phytyl-1,4-naphthoquinone
Other name(s): ndbB (gene name); NDC1 (gene name); demethylphylloquinone:NADPH oxidoreductase
Systematic name: NADPH:demethylphylloquinone oxidoreductase
Comments: The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Fatihi, A., Latimer, S., Schmollinger, S., Block, A., Dussault, P.H., Vermaas, W.F., Merchant, S.S. and Basset, G.J. A dedicated type II NADPH dehydrogenase performs the penultimate step in the biosynthesis of vitamin K1 in Synechocystis and Arabidopsis. Plant Cell 27 (2015) 1730–1741. [PMID: 26023160]
[EC 1.6.5.12 created 2015]
 
 


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