The Enzyme Database

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Accepted name: L-saccharopine oxidase
Reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + H2O + O2 = (S)-2-amino-6-oxohexanoate + L-glutamate + H2O2
Glossary: L-saccharopine = N6-(L-1,3-dicarboxypropyl)-L-lysine
(S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine
Other name(s): FAP2
Systematic name: L-saccharopine:oxygen oxidoreductase (L-glutamate forming)
Comments: The enzyme is involved in pipecolic acid biosynthesis. A flavoprotein (FAD).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Yoshida, N., Akazawa, S., Katsuragi, T. and Tani, Y. Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe. J. Biosci. Bioeng. 97 (2004) 278–280. [PMID: 16233628]
2.  Wickwire, B.M., Wagner, C. and Broquist, H.P. Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: a unique flavin enzyme involved in pipecolic acid biosynthesis. J. Biol. Chem. 265 (1990) 14748–14753. [PMID: 2394693]
[EC created 2011]

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