For diagram of fumigaclavin alkaloid biosynthesis, click here
festuclavine = 6,8β-dimethylergoline
FgaFS; festuclavine synthase
The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The reaction proceeds in vivo in the opposite direction to the one shown here.
Wallwey, C., Matuschek, M., Xie, X.L. and Li, S.M. Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3. Org. Biomol. Chem.8 (2010) 3500–3508. [DOI] [PMID: 20526482]