The Enzyme Database

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EC 1.5.1.44     
Accepted name: festuclavine dehydrogenase
Reaction: festuclavine + NAD+ = 6,8-dimethyl-6,7-didehydroergoline + NADH + H+
For diagram of fumigaclavin alkaloid biosynthesis, click here
Glossary: festuclavine = 6,8β-dimethylergoline
Other name(s): FgaFS; festuclavine synthase
Systematic name: festuclavine:NAD+ oxidoreductase
Comments: The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The reaction proceeds in vivo in the opposite direction to the one shown here.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Wallwey, C., Matuschek, M., Xie, X.L. and Li, S.M. Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3. Org. Biomol. Chem. 8 (2010) 3500–3508. [PMID: 20526482]
[EC 1.5.1.44 created 2012]
 
 


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