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Accepted name: 1,2-dehydroreticulinium reductase (NADPH)
R)-reticuline + NADP = 1,2-dehydroreticulinium + NADPH + H + +
For diagram of thebaine biosynthesis,
Other name(s): 1,2-dehydroreticulinium ion reductase
Systematic name: (
R)-reticuline:NADP oxidoreductase +
Comments: Reduces the 1,2-dehydroreticulinium ion to (
R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant. The enzyme does not catalyse the reverse reaction to any significant extent under physiological conditions.
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 130590-58-8
De-Eknamkul, W. and Zenk, M.H. Purification and properties of 1,2-dehydroreticulinium reductase from
Papaver somniferum seedlings. Phytochemistry 31 (1992) 813–821.
[EC 188.8.131.52 created 1999, modified 2004]
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