The Enzyme Database

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EC 1.4.9.2     
Accepted name: aralkylamine dehydrogenase (azurin)
Reaction: ArCH2NH2 + H2O + 2 azurin = ArCHO + NH3 + 2 reduced azurin
Glossary: azurin = an electron-transfer protein containing a type-1 copper site
Other name(s): aromatic amine dehydrogenase; arylamine dehydrogenase; tyramine dehydrogenase; aralkylamine:(acceptor) oxidoreductase (deaminating)
Systematic name: aralkylamine:azurin oxidoreductase (deaminating)
Comments: Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Iwaki, M., Yagi, T., Horiike, K., Saeki, Y., Ushijima, T. and Nozaki, M. Crystallization and properties of aromatic amine dehydrogenase from Pseudomonas sp. Arch. Biochem. Biophys. 220 (1983) 253–262. [PMID: 6830237]
2.  Hyun, Y.L. and Davidson, V.L. Electron transfer reactions between aromatic amine dehydrogenase and azurin. Biochemistry 34 (1995) 12249–12254. [PMID: 7547967]
3.  Hyun, Y.L., Zhu, Z. and Davidson, V.L. Gated and ungated electron transfer reactions from aromatic amine dehydrogenase to azurin. J. Biol. Chem. 274 (1999) 29081–29086. [PMID: 10506161]
4.  Davidson, V.L. Electron transfer in quinoproteins. Arch. Biochem. Biophys. 428 (2004) 32–40. [PMID: 15234267]
5.  Sukumar, N., Chen, Z.W., Ferrari, D., Merli, A., Rossi, G.L., Bellamy, H.D., Chistoserdov, A., Davidson, V.L. and Mathews, F.S. Crystal structure of an electron transfer complex between aromatic amine dehydrogenase and azurin from Alcaligenes faecalis. Biochemistry 45 (2006) 13500–13510. [PMID: 17087503]
[EC 1.4.9.2 created 1986 as EC 1.4.99.4, transferred 2011 to 1.4.9.2]
 
 


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