| EC |
1.3.99.38 |
| Accepted name: |
menaquinone-9 β-reductase |
| Reaction: |
menaquinone-9 + reduced acceptor = β-dihydromenaquinone-9 + acceptor |
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For diagram of vitamin K biosynthesis, click here |
| Glossary: |
β-dihydromenaquinone-9 = MK-9(II-H2) = 2-methyl-3-[(2E,10E,14E,18E,22E,26E,30E,33E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,10,14,18,22,26,30,33-octaen-1-yl]naphthalene-1,4-dione |
| Other name(s): |
MenJ |
| Systematic name: |
menaquinone-9 oxidoreductase (β-dihydromenaquinone-9-forming) |
| Comments: |
The enzyme from the bacterium Mycobacterium tuberculosis reduces the β-isoprene unit of menaquinone-9, forming the predominant form of menaquinone found in mycobacteria. Contains FAD. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Upadhyay, A., Fontes, F.L., Gonzalez-Juarrero, M., McNeil, M.R., Crans, D.C., Jackson, M. and Crick, D.C. Partial saturation of menaquinone in Mycobacterium tuberculosis: function and essentiality of a novel reductase, MenJ. ACS Cent. Sci. 1 (2015) 292–302. [DOI] [PMID: 26436137] |
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| [EC 1.3.99.38 created 2017] |
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