The Enzyme Database

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Accepted name: secologanin synthase
Reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O
For diagram of secologanin biosynthesis, click here
Systematic name: loganin:oxygen oxidoreductase (ring-cleaving)
Comments: A heme-thiolate protein (P-450). Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 258339-71-8
1.  Yamamoto, H., Katano, N., Ooi, A. and Inoue, K. Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P-450. Phytochemistry 53 (2000) 7–12. [PMID: 10656401]
2.  Irmler, S., Schroder, G., St-Pierre, B., Crouch, N.P., Hotze, M., Schmidt, J., Strack, D., Matern, U. and Schroder, J. Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P-450 CYP72A1 as secologanin synthase. Plant J. 24 (2000) 797–804. [PMID: 11135113]
3.  Yamamoto, H., Katano, N., Ooi, Y. and Inoue, K. Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures. Phytochemistry 50 (1999) 417–422.
[EC created 2002]

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