| EC |
1.3.1.70 |
| Accepted name: |
Δ14-sterol reductase |
| Reaction: |
4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol + NADP+ = 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol + NADPH + H+ |
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For diagram of the modification of sterol rings B, C and D, click here |
| Systematic name: |
4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol:NADP+ Δ14-oxidoreductase |
| Comments: |
This enzyme acts on a range of steroids with a 14(15)-double bond. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 69403-07-2 |
| References: |
| 1. |
Bottema, C.K. and Parks, L.W. Δ14-Sterol reductase in Saccharomyces cerevisiae. Biochim. Biophys. Acta 531 (1978) 301–307. [DOI] [PMID: 32908] |
| 2. |
Paik, Y.K., Trzaskos, J.M., Shafice, A. and Gaylor, J.L. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent Δ8,14-steroid 14-reductase. J. Biol. Chem. 259 (1984) 13413–13423. [PMID: 6444198] |
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| [EC 1.3.1.70 created 2001] |
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