| EC |
1.3.1.48 |
| Accepted name: |
13,14-dehydro-15-oxoprostaglandin 13-reductase |
| Reaction: |
11α-hydroxy-9,15-dioxoprostanoate + NAD(P)+ = (13E)-11α-hydroxy-9,15-dioxoprost-13-enoate + NAD(P)H + H+ |
| Other name(s): |
15-oxo-Δ13-prostaglandin reductase; Δ13-15-ketoprostaglandin reductase; 15-ketoprostaglandin Δ13-reductase; prostaglandin Δ13-reductase; prostaglandin 13-reductase; (5Z)-(15S)-11α-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Δ13-oxidoreductase; (5Z)-11α-hydroxy-9,15-dioxoprost-5-enoate:NAD(P)+ Δ13-oxidoreductase |
| Systematic name: |
11α-hydroxy-9,15-dioxoprostanoate:NAD(P)+ Δ13-oxidoreductase |
| Comments: |
Reduces 13,14-dehydro-15-oxoprostaglandins to 13,14-dihydro derivatives. The enzyme from placenta is specific for NAD+. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 57406-74-3 |
| References: |
| 1. |
Hansen, H.S. Purification and assay of 15-ketoprostaglandin Δ13-reductase from bovine lung. Methods Enzymol. 86 (1982) 156–163. [PMID: 6290839] |
| 2. |
Jarabak, J. Isolation and properties of a 15-ketoprostaglandin Δ13-reductase from human placenta. Methods Enzymol. 86 (1982) 163–167. [PMID: 7132753] |
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| [EC 1.3.1.48 created 1990, modified 2014] |
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