The Enzyme Database

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EC 1.3.1.15     
Accepted name: dihydroorotate dehydrogenase (NADP+)
Reaction: (S)-dihydroorotate + NADP+ = orotate + NADPH + H+
Other name(s): orotate reductase; dihydro-orotic dehydrogenase; L-5,6-dihydro-orotate:NAD+ oxidoreductase; orotate reductase (NADPH)
Systematic name: (S)-dihydroorotate:NADP+ oxidoreductase
Comments: Binds FMN and FAD [2]. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NAD+ (EC 1.3.1.14) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor .
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37255-27-9
References:
1.  Taylor, W.H., Taylor, M.L. and Eames, D.F. Two functionally different dihydroorotic dehydrogenases in bacteria. J. Bacteriol. 91 (1966) 2251–2256. [PMID: 4380263]
2.  Udaka, S. and Vennesland, B. Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase. J. Biol. Chem. 237 (1962) 2018–2024. [PMID: 13923427]
[EC 1.3.1.15 created 1972, modified 2011]
 
 


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