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Accepted name: dihydroorotate dehydrogenase (NADP
S)-dihydroorotate + NADP = orotate + NADPH + H + +
Other name(s): orotate reductase; dihydro-orotic dehydrogenase;
L-5,6-dihydro-orotate:NAD oxidoreductase; orotate reductase (NADPH) +
Systematic name: (
S)-dihydroorotate:NADP oxidoreductase +
Comments: Binds FMN and FAD . Other class 1 dihydroorotate dehydrogenases use either fumarate (
EC 18.104.22.168) or NAD ( + EC 22.214.171.124) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase ( EC 126.96.36.199) uses quinone as electron acceptor .
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37255-27-9
Taylor, W.H., Taylor, M.L. and Eames, D.F. Two functionally different dihydroorotic dehydrogenases in bacteria.
J. Bacteriol. 91 (1966) 2251–2256. [PMID: 4380263]
Udaka, S. and Vennesland, B. Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase.
J. Biol. Chem. 237 (1962) 2018–2024. [PMID: 13923427]
[EC 188.8.131.52 created 1972, modified 2011]
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