The Enzyme Database

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EC 1.3.1.12     
Accepted name: prephenate dehydrogenase
Reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH
For diagram of phenylalanine and tyrosine biosynthesis, click here
Other name(s): hydroxyphenylpyruvate synthase; chorismate mutase—prephenate dehydrogenase
Systematic name: prephenate:NAD+ oxidoreductase (decarboxylating)
Comments: This enzyme in the enteric bacteria also possesses chorismate mutase activity (EC 5.4.99.5 chorismate mutase) and converts chorismate into prephenate.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9044-92-2
References:
1.  Koch, G.L.E., Shaw, D.C. and Gibson, F. Tyrosine biosynthesis in Aerobacter aerogenes. Purification and properties of chorismate mutase-prephenate dehydrogenase. Biochim. Biophys. Acta 212 (1970) 375–386. [PMID: 5456988]
[EC 1.3.1.12 created 1972]
 
 


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