EC |
1.3.1.12 |
Accepted name: |
prephenate dehydrogenase |
Reaction: |
prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH |
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For diagram of phenylalanine and tyrosine biosynthesis, click here |
Other name(s): |
hydroxyphenylpyruvate synthase; chorismate mutase—prephenate dehydrogenase |
Systematic name: |
prephenate:NAD+ oxidoreductase (decarboxylating) |
Comments: |
This enzyme in the enteric bacteria also possesses chorismate mutase activity (EC 5.4.99.5 chorismate mutase) and converts chorismate into prephenate. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9044-92-2 |
References: |
1. |
Koch, G.L.E., Shaw, D.C. and Gibson, F. Tyrosine biosynthesis in Aerobacter aerogenes. Purification and properties of chorismate mutase-prephenate dehydrogenase. Biochim. Biophys. Acta 212 (1970) 375–386. [DOI] [PMID: 5456988] |
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[EC 1.3.1.12 created 1972] |
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