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Your query returned 1 entry. 
Printable version
| EC | 1.3.1.107 | ||||
| Accepted name: | sanguinarine reductase | ||||
| Reaction: | (1) dihydrosanguinarine + NAD(P)+ = sanguinarine + NAD(P)H + H+ (2) dihydrochelirubine + NAD(P)+ = chelirubine + NAD(P)H + H+ |
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| For diagram of chelirubine, macarpine and sanguinarine biosynthesis, click here | |||||
| Glossary: | sanguinarine = 13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4′,5′:4,5]benzo[1,2-c]phenanthridinium dihydrosanguinarine = 13-methyl-13,14-dihydro-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4′,5′:4,5]benzo[1,2-c]phenanthridine chelirubine = 5-methoxy-13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4′,5′:4,5]benzo[1,2-c]phenanthridinium dihydrochelirubine = 5-methoxy-13-methyl-13,14-dihydro-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4′,5′:4,5]benzo[1,2-c]phenanthridinium |
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| Systematic name: | dihydrosanguinarine:NAD(P)+ oxidoreductase | ||||
| Comments: | The enzyme, purified from the California poppy (Eschscholzia californica), is involved in detoxifying the phytoalexin sanguinarine produced by poppy itself (cf. EC 1.5.3.12, dihydrobenzophenanthridine oxidase), when it binds to the cell wall of the poppy cell. The reaction with NADPH is up to three times faster than that with NADH at low concentrations (<10 uM) of the dinucleotide. At higher concentrations the reaction with NADPH is inhibited but not that with NADH [1]. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
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