The Enzyme Database

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EC 1.3.1.102     
Accepted name: 2-alkenal reductase (NADP+)
Reaction: an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+
Other name(s): NADPH-dependent alkenal/one oxidoreductase; NADPH:2-alkenal α,β-hydrogenase
Systematic name: n-alkanal:NADP+ 2-oxidoreductase
Comments: Shows highest activity with 1-nitrocyclohexene but also has significant activity with 2-methylpentenal and trans-cinnamaldehyde [3]. Involved in the detoxication of α,β-unsaturated aldehydes and ketones. Has very low activity with NAD as reductant (cf. EC 1.3.1.74, 2-alkenal reductase [NAD(P)+]).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Hirata, T., Tamura, Y., Yokobatake, N., Shimoda, K. and Ashida, Y. A 38 kDa allylic alcohol dehydrogenase from the cultured cells of Nicotiana tabacum. Phytochemistry 55 (2000) 297–303. [PMID: 11117876]
2.  Matsushima, A., Sato, Y., Otsuka, M., Watanabe, T., Yamamoto, H. and Hirata, T. An enone reductase from Nicotiana tabacum: cDNA cloning, expression in Escherichia coli, and reduction of enones with the recombinant proteins. Bioorg. Chem. 36 (2008) 23–28. [PMID: 17945329]
3.  Mansell, D.J., Toogood, H.S., Waller, J., Hughes, J.M.X., Levy, C.W., Gardiner, J.M., and Scrutton, N.S. Biocatalytic asymmetric alkene reduction: crystal structure and characterization of a double bond reductase from Nicotiana tabacum. ACS Catal. 3 (2013) 370–379.
[EC 1.3.1.102 created 2013]
 
 


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