EC 1.21.3.2     
Accepted name: columbamine oxidase
Reaction: 2 columbamine + O2 = 2 berberine + 2 H2O
Other name(s): berberine synthase
Systematic name: columbamine:oxygen oxidoreductase (cyclizing)
Comments: An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine.
References:
1.  Rueffer, M. and Zenk, M.H. Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis. Tetrahedron Lett. 26 (1985) 201–202.
[EC 1.21.3.2 created 1989 as EC 1.1.3.26, transferred 2002 to EC 1.21.3.2]
 
 


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