The Enzyme Database

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Accepted name: arsenate reductase (azurin)
Reaction: arsenite + H2O + 2 oxidized azurin = arsenate + 2 reduced azurin + 2 H+
For diagram of arsenate catabolism, click here
Glossary: Azurin is a blue copper protein found in many bacteria, which undergoes oxidation-reduction between Cu(I) and Cu(II), and transfers single electrons between enzymes.
Other name(s): arsenite oxidase (ambiguous)
Systematic name: arsenite:azurin oxidoreductase
Comments: Contains a molybdopterin centre comprising two molybdopterin guanosine dinucleotide cofactors bound to molybdenum, a [3Fe-4S] cluster and a Rieske-type [2Fe-2S] cluster. Isolated from β-proteobacteria. Also uses a c-type cytochrome or O2 as acceptors.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, UM-BBD, CAS registry number: 146907-46-2
1.  Anderson, G.L., Williams, J. and Hille, R. The purification and characterization of arsenite oxidase from Alcaligenes faecalis, a molybdenum-containing hydroxylase. J. Biol. Chem. 267 (1992) 23674–23682. [PMID: 1331097]
2.  Ellis, P.J., Conrads, T., Hille, R. and Kuhn, P. Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in two crystal forms at 1.64 Å and 2.03 Å. Structure 9 (2001) 125–132. [PMID: 11250197]
[EC created 2001 as EC, transferred 2011 to EC]

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