The Enzyme Database

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EC 1.20.4.3     
Accepted name: mycoredoxin
Reaction: arseno-mycothiol + mycoredoxin = arsenite + mycothiol-mycoredoxin disulfide
Glossary: mycothiol = 1-O-[2-(N2-acetyl-L-cysteinamido)-2-deoxy--D-glucopyranosyl]-1D-myo-inositol
Other name(s): Mrx1; MrxI
Systematic name: arseno-mycothiol:mycoredoxin oxidoreductase
Comments: Reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate. The substrate arseno-mycothiol is formed by EC 2.8.4.2 (arsenate:mycothiol transferase). A second mycothiol recycles mycoredoxin and forms mycothione.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Ordonez, E., Van Belle, K., Roos, G., De Galan, S., Letek, M., Gil, J.A., Wyns, L., Mateos, L.M. and Messens, J. Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange. J. Biol. Chem. 284 (2009) 15107–15116. [PMID: 19286650]
[EC 1.20.4.3 created 2010]
 
 


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