| EC |
1.2.99.2 |
| Accepted name: |
carbon-monoxide dehydrogenase (acceptor) |
| Reaction: |
CO + H2O + A = CO2 + AH2 |
| Other name(s): |
anaerobic carbon monoxide dehydrogenase; carbon monoxide oxygenase; carbon-monoxide dehydrogenase; carbon-monoxide:(acceptor) oxidoreductase |
| Systematic name: |
carbon-monoxide:acceptor oxidoreductase |
| Comments: |
Contains a [Ni3Fe-4S] cluster and [4Fe-4S] clusters. It uses many electron acceptors, including ferredoxin, methyl viologen and benzyl viologen and flavins, but not pyridine nucleotides. Forms part of a membrane-bound multienzyme complex with EC 1.12.99.6, hydrogenase (acceptor), which catalyses the overall reaction: CO + H2O = CO2 + H2. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, UM-BBD, CAS registry number: 64972-88-9 |
| References: |
| 1. |
Bonam, D. and Ludden, P.W. Purification and characterization of carbon monoxide dehydrogenase, a nickel, zinc, iron-sulfur protein, from Rhodospirillum rubrum. J. Biol. Chem. 262 (1987) 2980–2987. [PMID: 3029096] |
| 2. |
Diekert, G. and Ritter, M. Purification of the nickel protein carbon monoxide dehydrogenase of Clostridium thermoaceticum. FEBS Lett. 151 (1983) 41–44. [PMID: 6687458] |
| 3. |
Drennan, C.L., Heo, J., Sintchak, M.D., Schreiter, E. and Ludden, P.W. Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase. Proc. Natl. Acad. Sci. USA 98 (2001) 11973–11978. [PMID: 11593006] |
| 4. |
Dobbek, H., Svetlitchnyi, V., Gremer, L., Huber, R. and Meyer, O. Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster. Science 293 (2001) 1281–1285. [PMID: 11509720] |
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| [EC 1.2.99.2 created 1982, modified 1990, modified 2003] |
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