The Enzyme Database

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Accepted name: carbon-monoxide dehydrogenase (acceptor)
Reaction: CO + H2O + A = CO2 + AH2
Other name(s): anaerobic carbon monoxide dehydrogenase; carbon monoxide oxygenase; carbon-monoxide dehydrogenase; carbon-monoxide:(acceptor) oxidoreductase
Systematic name: carbon-monoxide:acceptor oxidoreductase
Comments: Contains a [Ni3Fe-4S] cluster and [4Fe-4S] clusters. It uses many electron acceptors, including ferredoxin, methyl viologen and benzyl viologen and flavins, but not pyridine nucleotides. Forms part of a membrane-bound multienzyme complex with EC, hydrogenase (acceptor), which catalyses the overall reaction: CO + H2O = CO2 + H2.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, UM-BBD, CAS registry number: 64972-88-9
1.  Bonam, D. and Ludden, P.W. Purification and characterization of carbon monoxide dehydrogenase, a nickel, zinc, iron-sulfur protein, from Rhodospirillum rubrum. J. Biol. Chem. 262 (1987) 2980–2987. [PMID: 3029096]
2.  Diekert, G. and Ritter, M. Purification of the nickel protein carbon monoxide dehydrogenase of Clostridium thermoaceticum. FEBS Lett. 151 (1983) 41–44. [PMID: 6687458]
3.  Drennan, C.L., Heo, J., Sintchak, M.D., Schreiter, E. and Ludden, P.W. Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase. Proc. Natl. Acad. Sci. USA 98 (2001) 11973–11978. [PMID: 11593006]
4.  Dobbek, H., Svetlitchnyi, V., Gremer, L., Huber, R. and Meyer, O. Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster. Science 293 (2001) 1281–1285. [PMID: 11509720]
[EC created 1982, modified 1990, modified 2003]

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