ExplorEnz: EC 1.2.1.83

Your query returned 1 entry. Printable version

1.2.1.83

Accepted name:

3-succinoylsemialdehyde-pyridine dehydrogenase

Reaction:

4-oxo-4-(pyridin-3-yl)butanal + NADP⁺ + H₂O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H⁺

Glossary:

4-oxo-4-(pyridin-3-yl)butanal = 3-succinoylsemialdehyde-pyridine
4-oxo-4-(3-pyridyl)-butanoate = 3-succinoyl-pyridine

Systematic name:

4-oxo-4-(pyridin-3-yl)butanal:NADP⁺ oxidoreductase

Comments:

The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Qiu, J., Ma, Y., Wen, Y., Chen, L., Wu, L. and Liu, W. Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine. Appl. Environ. Microbiol. 78 (2012) 2154–2160. [DOI] [PMID: 22267672]

[EC 1.2.1.83 created 2012]