ExplorEnz: EC 1.2.1.74

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1.2.1.74

Accepted name:

abieta-7,13-dien-18-al dehydrogenase

Reaction:

abieta-7,13-dien-18-al + H₂O + NAD⁺ = abieta-7,13-dien-18-oate + NADH + H⁺

For diagram of abietadiene, abietate, isopimaradiene, labdadienol and sclareol biosynthesis, click here

Glossary:

abieta-7,13-dien-18-al = (1R,4aR,4bR,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carbaldehyde
abieta-7,13-dien-18-oate = (1R,4aR,4bR,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylate

Other name(s):

abietadienal dehydrogenase (ambiguous)

Systematic name:

abieta-7,13-dien-18-al:NAD⁺ oxidoreductase

Comments:

Abietic acid is the principle component of conifer resin. This enzyme catalyses the last step of the pathway of abietic acid biosynthesis in Abies grandis (grand fir). The activity has been demonstrated in cell-free stem extracts of A. grandis, was present in the cytoplasm, and required NAD⁺ as cofactor [1]. The enzyme is expressed constitutively at a high level, and is not inducible by wounding of the plant tissue [2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Funk, C. and Croteau, R. Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis. Arch. Biochem. Biophys. 308 (1994) 258–266. [DOI] [PMID: 8311462]
2.	Funk, C., Lewinsohn, E., Vogel, B.S., Steele, C.L. and Croteau, R. Regulation of oleoresinosis in grand fir (Abies grandis) (coordinate induction of monoterpene and diterpene cyclases and two cytochrome P450-dependent diterpenoid hydroxylases by stem wounding). Plant Physiol. 106 (1994) 999–1005. [PMID: 12232380]

[EC 1.2.1.74 created 2009, modified 2012]