ExplorEnz: EC 1.2.1.70

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1.2.1.70

Accepted name:

glutamyl-tRNA reductase

Reaction:

L-glutamate 1-semialdehyde + NADP⁺ + tRNA^Glu = L-glutamyl-tRNA^Glu + NADPH + H⁺

For diagram of the early stages of porphyrin biosynthesis, click here

Systematic name:

L-glutamate-semialdehyde:NADP⁺ oxidoreductase (L-glutamyl-tRNA^Glu-forming)

Comments:

This enzyme forms part of the pathway for the biosynthesis of 5-aminolevulinate from glutamate, known as the C5 pathway. The route shown in the diagram is used in most eubacteria, and in all archaebacteria, algae and plants. However, in the α-proteobacteria, EC 2.3.1.37, 5-aminolevulinate synthase, is used in an alternative route to produce the product 5-aminolevulinate from succinyl-CoA and glycine. This route is found in the mitochondria of fungi and animals, organelles that are considered to be derived from an endosymbiotic α-proteobacterium. Although higher plants do not possess EC 2.3.1.37, the protistan Euglena gracilis possesses both the C5 pathway and EC 2.3.1.37.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 119940-26-0

References:

1.	von Wettstein, D., Gough, S. and Kannangara, C.G. Chlorophyll biosynthesis. Plant Cell 7 (1995) 1039–1057. [DOI] [PMID: 12242396]
2.	Pontoppidan, B. and Kannangara, C.G. Purification and partial characterisation of barley glutamyl-tRNA^Glu reductase, the enzyme that directs glutamate to chlorophyll biosynthesis. Eur. J. Biochem. 225 (1994) 529–537. [DOI] [PMID: 7957167]
3.	Schauer, S., Chaturvedi, S., Randau, L., Moser, J., Kitabatake, M., Lorenz, S., Verkamp, E., Schubert, W.D., Nakayashiki, T., Murai, M., Wall, K., Thomann, H.-U., Heinz, D.W., Inokuchi, H, Söll, D. and Jahn, D. Escherichia coli glutamyl-tRNA reductase. Trapping the thioester intermediate. J. Biol. Chem. 277 (2002) 48657–48663. [DOI] [PMID: 12370189]

[EC 1.2.1.70 created 2004]