The Enzyme Database

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EC 1.2.1.58     
Accepted name: phenylglyoxylate dehydrogenase (acylating)
Reaction: phenylglyoxylate + NAD+ + CoA = benzoyl-S-CoA + CO2 + NADH
Systematic name: phenylglyoxylate:NAD+ oxidoreductase
Comments: Requires thiamine diphosphate as cofactor. The enzyme from the denitrifying bacterium Azoarcus evansii is specific for phenylglyoxylate. 2-Oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate. Also reduces viologen dyes. Contains iron-sulfur centres and FAD.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 205510-78-7
References:
1.  Hirsch, W., Schägger, H. and Fuchs, G. Phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Axoarcus evansii. Eur. J. Biochem. 251 (1998) 907–915. [PMID: 9490067]
[EC 1.2.1.58 created 1999]
 
 


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