| EC |
1.17.98.4 |
| Accepted name: |
formate dehydrogenase (hydrogenase) |
| Reaction: |
formate + an [oxidized hydrogenase] = CO2 + a [reduced hydrogenase] |
| Other name(s): |
FDHH; FDH-H; FDH-O; formate dehydrogenase H; formate dehydrogenase O |
| Systematic name: |
formate:[oxidized hydrogenase] oxidoreductase |
| Comments: |
Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes formate without oxygen transfer, transferring electrons to a hydrogenase. The two enzymes form the formate-hydrogen lyase complex [1]. The enzyme contains an [4Fe-4S] cluster, a selenocysteine residue and a molybdopterin cofactor [1]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Axley, M.J., Grahame, D.A. and Stadtman, T.C. Escherichia coli formate-hydrogen lyase. Purification and properties of the selenium-dependent formate dehydrogenase component. J. Biol. Chem. 265 (1990) 18213–18218. [PMID: 2211698] |
| 2. |
Gladyshev, V.N., Boyington, J.C., Khangulov, S.V., Grahame, D.A., Stadtman, T.C. and Sun, P.D. Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis. J. Biol. Chem. 271 (1996) 8095–8100. [DOI] [PMID: 8626495] |
| 3. |
Khangulov, S.V., Gladyshev, V.N., Dismukes, G.C. and Stadtman, T.C. Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer. Biochemistry 37 (1998) 3518–3528. [DOI] [PMID: 9521673] |
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| [EC 1.17.98.4 created 2010 as EC 1.1.99.33, transferred 2018 to EC 1.17.99.7, transferred 2020 to 1.17.98.4.] |
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