The Enzyme Database

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EC 1.17.4.2     
Accepted name: ribonucleoside-triphosphate reductase
Reaction: 2′-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin
Other name(s): ribonucleotide reductase; 2′-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2′-oxidoreductase
Systematic name: 2′-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2′-oxidoreductase
Comments: Requires a cobamide coenzyme and ATP.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9068-66-0
References:
1.  Blakley, R.L. Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii. J. Biol. Chem. 240 (1965) 2173–2180. [PMID: 14299643]
2.  Goulian, M. and Beck, W.S. Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii. J. Biol. Chem. 241 (1966) 4233–4242. [PMID: 5924645]
3.  Lammers, M. and Follmann, H. The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation. Struct. Bonding 54 (1983) 27–91.
[EC 1.17.4.2 created 1972]
 
 


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