The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre . Together with EC 184.108.40.206 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.
Jollie, D.R. and Lipscomb, J.D. Formate dehydrogenase from Methylosinus trichosporium OB3b. Purification and spectroscopic characterization of the cofactors. J. Biol. Chem.266 (1991) 21853–21863. [PMID: 1657982]
[EC 220.127.116.11 created 1961 as EC 18.104.22.168, transferred 2017 to EC 22.214.171.124]