The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 1.16.1.10     
Accepted name: ferric-chelate reductase [NAD(P)H]
Reaction: 2 Fe(II)-siderophore + NAD(P)+ + H+ = 2 Fe(III)-siderophore + NAD(P)H
Other name(s): ferric reductase (ambiguous)
Systematic name: Fe(II)-siderophore:NAD(P)+ oxidoreductase
Comments: A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Vadas, A., Monbouquette, H.G., Johnson, E. and Schroder, I. Identification and characterization of a novel ferric reductase from the hyperthermophilic Archaeon Archaeoglobus fulgidus. J. Biol. Chem. 274 (1999) 36715–36721. [PMID: 10593977]
2.  Chiu, H.J., Johnson, E., Schroder, I. and Rees, D.C. Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+. Structure 9 (2001) 311–319. [PMID: 11525168]
[EC 1.16.1.10 created 2014]
 
 


Data © 2001–2016 IUBMB
Web site © 2005–2016 Andrew McDonald