The Enzyme Database

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EC 1.14.99.49     
Accepted name: 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase
Reaction: 2-hydroxy-5-methyl-1-naphthoate + reduced acceptor + O2 = 2,7-dihydroxy-5-methyl-1-naphthoate + oxidized acceptor + H2O
For diagram of neocarzinostatin biosynthesis, click here
Other name(s): NcsB3
Systematic name: 2-hydroxy-5-methyl-1-naphthoate,hydrogen-donor:oxygen oxidoreductase (7-hydroxylating)
Comments: A heme-thiolate protein (P-450) enzyme involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Hang, V.T.T., Oh, T.J., Yamaguchi, T. and Sohng, J.K. In vivo characterization of NcsB3 to establish the complete biosynthesis of the naphthoic acid moiety of the neocarzinostatin chromophore. FEMS Microbiol. Lett. 311 (2010) 119–125. [PMID: 20735485]
[EC 1.14.99.49 created 2014]
 
 


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