| EC |
1.14.99.44 |
| Accepted name: |
diapolycopene oxygenase |
| Reaction: |
4,4′-diapolycopene + 4 reduced acceptor + 4 O2 = 4,4′-diapolycopenedial + 4 acceptor + 6 H2O |
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For diagram of C30 carotenoid biosynthesis, click here |
| Other name(s): |
crtP (ambiguous) |
| Systematic name: |
4,4′-diapolycopene,AH2:oxygen oxidoreductase (4,4′-hydroxylating) |
| Comments: |
Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Mijts, B.N., Lee, P.C. and Schmidt-Dannert, C. Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution. Chem. Biol. 12 (2005) 453–460. [DOI] [PMID: 15850982] |
| 2. |
Tao, L., Schenzle, A., Odom, J.M. and Cheng, Q. Novel carotenoid oxidase involved in biosynthesis of 4,4′-diapolycopene dialdehyde. Appl. Environ. Microbiol. 71 (2005) 3294–3301. [DOI] [PMID: 15933032] |
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| [EC 1.14.99.44 created 2011] |
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