The Enzyme Database

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EC 1.14.99.44     
Accepted name: diapolycopene oxygenase
Reaction: 4,4′-diapolycopene + 4 AH2 + 4 O2 = 4,4′-diapolycopenedial + 4 A + 6 H2O
For diagram of C30 carotenoid biosynthesis, click here
Other name(s): crtP (ambiguous)
Systematic name: 4,4′-diapolycopene,AH2:oxygen oxidoreductase (4,4′-hydroxylating)
Comments: Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Mijts, B.N., Lee, P.C. and Schmidt-Dannert, C. Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution. Chem. Biol. 12 (2005) 453–460. [PMID: 15850982]
2.  Tao, L., Schenzle, A., Odom, J.M. and Cheng, Q. Novel carotenoid oxidase involved in biosynthesis of 4,4′-diapolycopene dialdehyde. Appl. Environ. Microbiol. 71 (2005) 3294–3301. [PMID: 15933032]
[EC 1.14.99.44 created 2011]
 
 


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