The Enzyme Database

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Accepted name: zeaxanthin 7,8-dioxygenase
Reaction: zeaxanthin + 2 O2 = crocetin dialdehyde + 2 (3S)-3-hydroxycyclocitral (overall reaction)
(1a) zeaxanthin + O2 = β-citraurin + (3S)-3-hydroxycyclocitral
(1b) β-citraurin + O2 = crocetin dialdehyde + (3S)-3-hydroxycyclocitral
For diagram of crocin biosynthesis, click here
Glossary: β-citraurin = 3-hydroxy-β-apo-8′-carotenal
Other name(s): zeaxanthin 7,8(7′,8′)-cleavage dioxygenase; CsZCD (incorrect); CCD2 (gene name)
Systematic name: zeaxanthin:oxygen oxidoreductase (7,8-cleaving)
Comments: The enzyme, characterized from the plant Crocus sativus, acts twice on zeaxanthin, cleaving 3-hydroxycyclocitral off each 3-hydroxy end group. It is part of the zeaxanthin degradation pathway in that organism, leading to the different compounds that impart the color, flavor and aroma of the saffron spice.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Frusciante, S., Diretto, G., Bruno, M., Ferrante, P., Pietrella, M., Prado-Cabrero, A., Rubio-Moraga, A., Beyer, P., Gomez-Gomez, L., Al-Babili, S. and Giuliano, G. Novel carotenoid cleavage dioxygenase catalyzes the first dedicated step in saffron crocin biosynthesis. Proc. Natl. Acad. Sci. USA 111 (2014) 12246–12251. [PMID: 25097262]
[EC created 2011, modified 2014]

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