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Accepted name: progesterone monooxygenase
Reaction: progesterone + reduced acceptor + O
= testosterone acetate + acceptor + H 2 O 2
Other name(s): progesterone hydroxylase
Systematic name: progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
Comments: Has a wide specificity. A single enzyme from ascomycete the
Neonectria radicicola ( EC 188.8.131.52 ketosteroid monooxygenase) catalyses both this reaction and that catalysed by EC 184.108.40.206 androst-4-ene-3,17-dione monooxygenase.
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37256-85-2
Rahim, M.A. and Sih, C.J. Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain.
J. Biol. Chem. 241 (1966) 3615–3623. [PMID: 5950688]
[EC 220.127.116.11 created 1972, modified 1999]
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