The Enzyme Database

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EC 1.14.99.37     
Accepted name: taxadiene 5α-hydroxylase
Reaction: taxa-4,11-diene + AH2 + O2 = taxa-4(20),11-dien-5α-ol + A + H2O
For diagram of taxadiene hydroxylation, click here
Systematic name: taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5α-hydroxylating)
Comments: This microsomal cytochrome-P-450-dependent enzyme is involved in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel). The reaction includes rearrangement of the 4(5)-double bond to a 4(20)-double bond, possibly through allylic oxidation.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9035-51-2
References:
1.  Hefner, J., Rubenstein, S.M., Ketchum, R.E., Gibson, D.M., Williams, R.M. and Croteau, R. Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5α-ol: the first oxygenation step in taxol biosynthesis. Chem. Biol. 3 (1996) 479–489. [PMID: 8807878]
[EC 1.14.99.37 created 2002]
 
 


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