The Enzyme Database

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Accepted name: mycocyclosin synthase
Reaction: cyclo(L-tyrosyl-L-tyrosyl) + NADPH + H+ + O2 = mycocyclosin + NADP+ + 2 H2O
Glossary: mycocyclosin = (1S,14S)-6,9-dihydroxy-15,17-diazatetracyclo[,7.18,12]icosa-3(20),4,6,8(19),9,11-hexaene-16,18-dione
Other name(s): CYP121; rv2276 (gene name)
Systematic name: cyclo(L-tyrosyl-L-tyrosyl),NADPH:oxygen oxidoreductase (diarylbridge-forming)
Comments: A heme-thiolate (P-450) enzyme from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Belin, P., Le Du, M.H., Fielding, A., Lequin, O., Jacquet, M., Charbonnier, J.B., Lecoq, A., Thai, R., Courcon, M., Masson, C., Dugave, C., Genet, R., Pernodet, J.L. and Gondry, M. Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 106 (2009) 7426–7431. [DOI] [PMID: 19416919]
[EC created 2013]

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