The Enzyme Database

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EC 1.14.21.4     
Accepted name: salutaridine synthase
Reaction: (R)-reticuline + NADPH + H+ + O2 = salutaridine + NADP+ + 2 H2O
For diagram of thebaine biosynthesis, click here
Other name(s): (R)-reticuline oxidase (C-C phenol-coupling)
Systematic name: (R)-reticuline,NADPH:oxygen oxidoreductase (C-C phenol-coupling)
Comments: A heme-thiolate enzyme (P-450). Forms the morphinan alkaloid salutaridine by intramolecular phenol oxidation of reticuline without the incorporation of oxygen into the product.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 149433-84-1
References:
1.  Gerady, R. and Zenk, M.H. Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum. Phytochemistry 32 (1993) 79–86.
[EC 1.14.21.4 created 1999 as EC 1.1.3.35, transferred 2002 to EC 1.14.21.4]
 
 


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