| EC |
1.14.19.60 |
| Accepted name: |
7-chloro-L-tryptophan 6-halogenase |
| Reaction: |
7-chloro-L-tryptophan + FADH2 + chloride + O2 + H+ = 6,7-dichloro-L-tryptophan + FAD + 2 H2O |
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For diagram of chlorotryptophan biosynthesis, click here |
| Other name(s): |
ktzR (gene name) |
| Systematic name: |
7-chloro-L-tryptophan:FADH2 oxidoreductase (6-halogenating) |
| Comments: |
An FAD-dependent halogenase. The enzyme, characterized from the bacterium Kutzneria sp. 744, works in tandem with EC 1.14.19.9, tryptophan 7-halogenase, (ktzQ) to generate 6,7-dichloro-L-tryptophan, which is incorporated as a pyrroloindoline in the kutznerides family of natural products. It has a 120-fold preference for 7-chloro-L-tryptophan over L-tryptophan as substrate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Heemstra, J.R., Jr. and Walsh, C.T. Tandem action of the O2- and FADH2-dependent halogenases KtzQ and KtzR produce 6,7-dichlorotryptophan for kutzneride assembly. J. Am. Chem. Soc. 130 (2008) 14024–14025. [DOI] [PMID: 18828589] |
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| [EC 1.14.19.60 created 2018] |
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