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Your query returned 1 entry. Printable version
EC | 1.14.19.59 | ||||||
Accepted name: | tryptophan 6-halogenase | ||||||
Reaction: | (1) L-tryptophan + FADH2 + chloride + O2 + H+ = 6-chloro-L-tryptophan + FAD + 2 H2O (2) D-tryptophan + FADH2 + chloride + O2 + H+ = 6-chloro-D-tryptophan + FAD + 2 H2O |
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For diagram of chlorotryptophan biosynthesis, click here | |||||||
Other name(s): | sttH (gene name); thdH (gene name) | ||||||
Systematic name: | L-tryptophan:FADH2 oxidoreductase (6-halogenating) | ||||||
Comments: | The enzyme is a flavin-dependent halogenase that has been described from several bacterial species. It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion. The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate. cf. EC 1.14.19.58, tryptophan 5-halogenase, and EC 1.14.19.9, tryptophan 7-halogenase. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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